An integrated metabolomic and proteomic approach for the identification of covalent inhibitors of the main protease (Mpro) of SARS-COV-2 from crude natural extractsArticle Published on 2023-01-152022-11-15 Journal: Talanta [Category] SARS, 유전자 메커니즘, 치료제, [키워드] Analysis applied approach baicalein binding carried catalytic characteristic Chinese complementary complex Compound Covalent binder Cys145 database drug target electrophilic Final functional HIS163 HIS164 His41 independent inhibitor inhibitors Ion knowledge M pro M(pro) mass mass spectrometry maturation metabolomic metabolomics Michael molecular dynamics MPro nucleophilic peptide platform polyprotein protease protein-ligand Proteins proteomic proteomics residue SARS-CoV-2 SARS-CoV-2. Scutellaria baicalensis tested the SARS-CoV-2 [DOI] 10.1016/j.talanta.2022.123824 PMC 바로가기
A systematic review of the advancement on colorimetric nanobiosensors for SARS-CoV-2 detectionArticle Published on 2023-01-052022-11-15 Journal: Journal of pharmaceutical and biomedical analysis [Category] SARS, 진단, 치료기술, [키워드] addition analyzed applied approach articles biosensors chain Clinical diagnosis coronavirus COVID-19 database Detection limit Diagnosis devices diagnostic diagnostics Direct ELISA enzyme-linked immunosorbent assay faster highlight individual lateral flow immunoassay Masks Nanosensors original form pandemic PCR POC POC. point-of-care reaction researcher SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 viruses Science searched selective severe respiratory syndrome specificity surgical swabs systematic review virus detection Web of Science [DOI] 10.1016/j.jpba.2022.115087 PMC 바로가기
Electrochemical paper-based antigen sensing platform using plant-derived monoclonal antibody for detecting SARS-CoV-2Article Published on 2023-01-012022-11-15 Journal: Talanta [Category] SARS, 진단, 치료기술, 치료제, [키워드] anti-SARS-CoV-2 antibody Antigen applicability applied approach Cellulose Concentration COVID-19 diagnosis CR3022 detect diagnostic Differential pulse voltammetry expressed functional group limit of detection linear relationship monoclonal antibody nasopharyngeal swab sample Nicotiana benthamiana Paper-based electrochemical immunosensor Plant-based antibody platform point-of-care pulse quantification RBD Receptor binding domain Saliva SAR-CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2. Spike protein the RBD this system was performed [DOI] 10.1016/j.talanta.2022.123783 PMC 바로가기
Application of a high-throughput quantitative PCR system for simultaneous monitoring of SARS-CoV-2 variants and other pathogenic viruses in wastewaterArticle Published on 2022-12-202022-11-15 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] acute respiratory syndrome Alpha variant analyzed application applied assays can be used collected Community coronavirus coronavirus disease COVID-19 delta variant demonstrated detect eight epidemiologically FIVE Health High-throughput qPCR highlighting increase Japan L452R labor-intensive likelihood Mie N501Y nine nucleotide nucleotide substitution pathogenic virus pathogenic viruses Pathogenic viruses, SARS-CoV-2 Patient PCR positive prevalent qPCR quantitative PCR quarantine reported RNA RT-qPCR SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant separated Surveillance target tested time-consuming Treatment virus viruses Volume wastewater Wastewater. Yokkaichi [DOI] 10.1016/j.scitotenv.2022.158659 PMC 바로가기
Interleukin-18 and COVID-19Original Paper Published on 2022-12-162022-11-01 Journal: Epidemiology and Infection [Category] COVID-19, SARS, [키워드] 95% CI 95% confidence interval Analysis applied association conducted Coronavirus Disease (COVID)-19 COVID-19 cytokine estimate Evolutionary biology experimental design Exploratory analysis Genetic Genome-wide association study genome-wide significant hospitalised IFN Immunity interferon interferon gamma Interleukin-18 investigated less liberal lower risk Mendelian randomisation Odds ratio precursor predicted predictor predictors Prevent randomisation severe COVID-19 severity Standard deviation vulnerability was related with COVID-19 [DOI] 10.1017/S0950268821002636 PMC 바로가기 [Article Type] Original Paper
Application of neighborhood-scale wastewater-based epidemiology in low COVID-19 incidence situationsArticle Published on 2022-12-152022-11-16 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 변종, [키워드] application applied approach average characterized Concentration COVID-19 COVID-19 incidence Disease surveillance effective Epidemiology incidence rate infections less limit local outbreak Low COVID-19 incidence Mild N gene Neighborhood-scale sewersheds normalized outbreak plant public health measure quantification reported RT-qPCR SARS-CoV-2 SARS-CoV-2 N gene SARS-CoV-2 variant-specific RT-qPCR assays sensitivity Seven specificity statistically Surveillance the SARS-CoV-2 threshold Treatment virus Wastewater-based epidemiology. [DOI] 10.1016/j.scitotenv.2022.158448 PMC 바로가기
Evaluation of degradation performance toward antiviral drug ribavirin using advanced oxidation process and its relations to ecotoxicity evolutionResearch article Published on 2022-12-012022-10-05 Journal: The Science of the total environment [Category] 치료제, [키워드] addition Analysis antiviral drug antiviral drugs applied conditions coronavirus disease Degradation discharged ecosystem Ecotoxicity evaluation effort eliminated Evolution functional Health identify investigated liquid Quantitative ribavirin risk Spread Stage Toxicity Transformation products treated Treatment UV/TiO2/H2O2 process Wastewater treatment [DOI] 10.1016/j.scitotenv.2022.157851 [Article Type] Research article
Identification of the Hub Genes and the Signaling Pathways in Human iPSC-Cardiomyocytes Infected by SARS-CoV-2Article Published on 2022-12-012022-11-16 Journal: Biochemical Genetics [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Analysis applied Bioinformatics analysis biological process Biomarker Brain caused component Cytoscape software database dataset DEGs differentially expressed gene direct infection down-regulated gene enrichment analysis function Gene Expression Omnibus gene expression profile Gene ontology Genes GEO GraphPad Prism software High-throughput sequencing hub genes Human Human iPSC-cardiomyocytes identification infected with SARS-CoV-2 intestine KEGG kidney Kyoto Ligand liver Lung injury mechanisms myocardial injury organ pathway Pathways PPI PPI network protein-protein interaction R software receptor Research respiratory respiratory symptom SARS-CoV-2 SARS-CoV-2. screened sequencing data signaling pathway single-stranded RNA virus statistical analysis statistically significant TNF signaling Type type I interferon up-regulated was obtained was performed website [DOI] 10.1007/s10528-022-10206-7 PMC 바로가기
Genomic variants-driven drug repurposing for tuberculosis by utilizing the established bioinformatic-based approachShort communication Published on 2022-12-012022-10-05 Journal: Biochemistry and Biophysics Reports [Category] 신약개발, [키워드] annotations applied approach bioinformatics biological process CCR5 CD44 cellular component contribute CXCR4 demonstrated deregulation disease disease-associated drug Drug discovery Drug repurposing drug target evaluated Evidence facilitate functional functional annotation Genes genomic genomic variant genomic variants GWAS HLA-B identify implementation in-silico indication involved KEGG Missense mutation molecular overlapped Pathogenesis Pathway analysis provided risk SELP suggested target Treatment Tuberculosis variant [DOI] 10.1016/j.bbrep.2022.101334 [Article Type] Short communication
High sensitivity SARS-CoV-2 detection using graphene oxide-multiplex qPCRArticle Published on 2022-11-222022-11-15 Journal: Analytica chimica acta [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] acute respiratory syndrome amplification applied coronavirus detect detection diagnoses gold standard Graphene Graphene oxide high sensitivity limit of detection molecular multiplex Multiplex qPCR pandemic pathogen detection polymerase chain primer qPCR qPCR assay reduce reference gene RNase P RT-qPCR SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 gene SARS-CoV-2. sensitivity single-stranded DNA ssDNA target virus [DOI] 10.1016/j.aca.2022.340533 PMC 바로가기